AG Sendler

Aktuelle Projekte

Publikationen

Auswahl:

Mazloum H, Buchholz S, Schifter H, Ameling S, Steil L, Becker BL, Hammer E, Homuth G, Völker U, Bröker BM, Zierke L, Weiss FU, Glaubitz J, Sendler M. Interleukin-1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis Adv Sci (Weinh). 2026 Sep 3:e77558.

ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J IL-4/STAT6-signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis Adv Sci (Weinh). 2026 Jan 5:e15585.

Glaubitz J, Zimdahl A, Zeissig S, Weiss FU, Sendler M. Role of Interleukin-6 Mediated T Cell Activation in Experimental Acute Pancreatitis. Inflammation. 2025 Dec;48(6):4330-4341.

Modenbach JM, Möller C, Asgarbeik S, Geist N, Rimkus N, Dörr M, Wolfgramm H, Steil L, Susemihl A, Graf L, Schmöker O, Böttcher D, Hammer E, Glaubitz J, Lammers M, Delcea M, Völker U, Aghdassi AA, Lerch MM, Weiss FU, Bornscheuer UT, Sendler M. Biochemical analyses of cystatin-C dimers and cathepsin-B reveals a trypsin-driven feedback mechanism in acute pancreatitis Nat Commun. 2025 Feb 17;16(1):1702.

Lange R, Glaubitz J, Frost F, Geisz A, Aghdassi AA, Weiss FU, Sendler M. Examination of duodenal and colonic microbiome changes in mouse models of acute and chronic pancreatitis Sci Rep. 2024 Oct 21;14(1):24754.

Glaubitz J, Asgarbeik S, Lange R, Mazloum H, Elsheikh H, Weiss FU, Sendler M. Immune response mechanisms in acute and chronic pancreatitis: strategies for therapeutic intervention. Front. Immunol., 10 October 2023 Volume 14 – 2023

Thiel FG, Asgarbeik S, Glaubitz J, Wilden A, Lerch MM, Weiss FU, Sendler M. IRAK3-mediated suppression of pro-inflammatory MyD88/IRAK signaling affects disease severity in acute pancreatitis Sci Rep. 2023 Jul 4;13(1):10833.

Glaubitz J, Wilden A, Frost F, Ameling S, Homuth G, Mazloum H, Rühlemann MC, Bang C, Aghdassi AA, Budde C, Pickartz T, Franke A, Bröker BM, Voelker U, Mayerle J, Lerch MM, Weiss FU, Sendler M. Activated regulatory T-cells promote duodenal bacterial translocation into necrotic areas in severe acute pancreatitis Gut. 2023 Jan 11:gutjnl-2022-327448. 

Wilden A, Glaubitz J, Otto O, Biedenweg D, Nauck M, Mack M, Ribback S, Bröker BM, von Rheinbaben SF, Lerch MM, Aghdassi AA, Weiss FU, Sendler M. Mobilization of CD11b+/Ly6chi monocytes causes multi organ dysfunction syndrome in acute pancreatitis Front Immunol. 2022 Oct 10;13:991295.

Glaubitz J, Wilden A, Golchert J, Homuth G, Völker U, Bröker BM, Thiele T, Lerch MM, Mayerle J, Aghdassi AA, Weiss FU, Sendler M. In mouse chronic pancreatitis CD25+FOXP3+ regulatory T cells control pancreatic fibrosis by suppression of the type 2 immune response Nat Commun. 2022 Aug 3;13(1):4502. 

de Freitas Chama LL, Ebstein F, Wiesrecker B, Wagh PR, Hammer E, Weiss FU, Junker H, Studencka-Turski M, Lerch MM, Krüger E, Sendler M. Immunoproteasome impairment via β5i/LMP7-deletion leads to sustained pancreatic injury from experimental pancreatitis J Cell Mol Med. 2021 Jul;25(14):6786-6799.

Glaubitz J, Wilden A, van den Brandt C, Weiss FU, Bröker BM, Mayerle J, Lerch MM, Sendler M. Experimental pancreatitis is characterized by rapid T cell activation, Th2 differentiation that parallels disease severity, and improvement after CD4 + T cell depletion Pancreatology. 2020 Dec;20(8):1637-1647.

Sendler M, van den Brandt C, Glaubitz J, Wilden A, Golchert J, Weiss FU, Homuth G, De Freitas Chama LL, Mishra N, Mahajan UM, Bossaller L, Völker U, Bröker BM, Mayerle J, Lerch MM. NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis Gastroenterology. 2020 Jan;158(1):253-269.e14. 

Mayerle J, Sendler M, Hegyi E, Beyer G, Lerch MM, Sahin-Tóth M. Genetics, Cell Biology, and Pathophysiology of Pancreatitis Gastroenterology. 2019 May;156(7):1951-1968.e1.

Sendler M, Maertin S, John D, Persike M, Weiss FU, Krüger B, Wartmann T, Wagh P, Halangk W, Schaschke N, Mayerle J, Lerch MM. Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis. J Biol Chem. 2016 Jul 8;291(28):14717-31.

Mareninova OA, Sendler M, Malla SR, Yakubov I, French SW, Tokhtaeva E, Vagin O, Oorschot V, Lüllmann-Rauch R, Blanz J, Dawson D, Klumperman J, Lerch MM, Mayerle J, Gukovsky I, Gukovskaya AS. Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis. Cell Mol Gastroenterol Hepatol. 2015 Nov 1;1(6):678-694.

Sendler M, Weiss FU, Golchert J, Homuth G, van den Brandt C, Mahajan UM, Partecke LI, Döring P, Gukovsky I, Gukovskaya AS, Wagh PR, Lerch MM, Mayerle J. Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice. Gastroenterology. 2018 Feb;154(3):704-718.e10.

Sendler M, Beyer G, Mahajan UM, Kauschke V, Maertin S, Schurmann C, Homuth G, Völker U, Völzke H, Halangk W, Wartmann T, Weiss FU, Hegyi P, Lerch MM, Mayerle J. Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis. Gastroenterology. 2015 Sep;149(3):765-76.e10.

Sendler M, Dummer A, Weiss FU, Krüger B, Wartmann T, Scharffetter-Kochanek K, van Rooijen N, Malla SR, Aghdassi A, Halangk W, Lerch MM, Mayerle J. Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice. Gut. 2013 Mar;62(3):430-9.

Abgeschlossene Arbeiten

Doktorarbeiten:

  • Rabea Lange - 2026 - Dr. rer. nat. "Interleukin 10 und seine Rolle in der Typ-II-Immunantwort während der experimentellen akuten und chronischen Pankreatitis"
  • Hager Elsheikh - 2026 - Dr. rer. nat. "STAT6-mediated type II immune response during acute and chronic pancreatitis in mouse models "
  • Saeedeh Asgarbeik - 2025 Dr. rer. nat. "Endogenous inhibition of Cathepsin B regulates intracellular protease activation during acute pancreatitis"
  • Hala Mazloum - 2025 Dr. rer. nat. "Interleukin-1 Family: Key Regulators of Immune Response and Fibrosis in Acute and Chronic Pancreatitis"
  • Franziska G. Thiel - 2022 Dr. rer. nat. "Die Untersuchung der Rolle von IRAK-M während der experimentellen Pankreatitis"
  • Jana M. Modenbach - 2021 Dr. rer. nat. "Die Cystatin C-Hemmung von Cathepsin B ist ein entscheidender Schutzmechanismus des Pankreas gegen die Wirkung von vorzeitig aktivierten Verdauungsenzymen"
  • Juliane Glaubitz - 2021 Dr. rer. nat. "Untersuchungen zur suppressiven Wirkung regulatorischer T-Zellen auf den Verlauf der Pankreatitis im Mausmodell"
  • Anika Wilden - 2021 Dr. rer. nat. "Der Einfluss des Immunsystems auf den Organschaden in der schweren akute Pankreatitis und die Rolle von Interleukin 33 im Mausmodell"

Bachelor- und Masterarbeiten:

  • Judith Piesker - 2025 B.Sc. "Der Einfluss des Transkriptionsfaktors STAT6 auf die Pro-Inflammation und Organregeneration während der akuten Pankreatitis"
  • Annika Salvers - 2025 B.Sc. "Der Einfluss der IL-4/IL-13-STAT6-Achse auf die Aktivierung pankreatischer Fibroblasten"
  • Shenja Buchholz - 2024 M.Sc. "Interplay between gut microbiome an the gut immune response during a mouse model of acute pancreatitis"
  • Anna Zimdahl - 2024 B.Sc. "Die Rolle von Interleukin-6 auf die Immunantwort im Verlauf der akuten Pankreatitis"