array(4 items)
   caller => 'TYPO3\CMS\Core\Database\DatabaseConnection::exec_SELECTquery' (60 chars)
   ERROR => 'Disk full (/tmp/#sql_2d4_0.MAI); waiting for someone to free some space... (
      errno: 28 "No space left on device")' (112 chars)
   lastBuiltQuery => 'SELECT uid,title,tstamp,description,subtitle,tt_news_related_mm.tablenames F
      ROM pages,tt_news_related_mm WHERE tt_news_related_mm.uid_local=34
					AND 
      pages.uid=tt_news_related_mm.uid_foreign
					AND tt_news_related_mm.tablena
      mes='pages' AND pages.deleted=0 AND pages.t3ver_state<=0 AND pages.pid<>-1 A
      ND pages.hidden=0 AND pages.starttime<=1778724840 AND (pages.endtime=0 OR pa
      ges.endtime>1778724840) AND (pages.fe_group='' OR pages.fe_group IS NULL OR 
      pages.fe_group='0' OR FIND_IN_SET('0',pages.fe_group) OR FIND_IN_SET('-1',pa
      ges.fe_group)) ORDER BY title' (561 chars)
   debug_backtrace => '{closure}#34 // TYPO3\CMS\Frontend\Http\Application->run#33 // TYPO3\CMS\Cor
      e\Core\Bootstrap->handleRequest#78 // TYPO3\CMS\Frontend\Http\RequestHandler
      ->handleRequest#307 // TYPO3\CMS\Frontend\Page\PageGenerator::renderContent#
      216 // TYPO3\CMS\Frontend\ContentObject\ContentObjectRenderer->cObjGet#210 /
      / TYPO3\CMS\Frontend\ContentObject\ContentObjectRenderer->cObjGetSingle#805 
      // TYPO3\CMS\Frontend\ContentObject\ContentObjectRenderer->render#859 // TYP
      O3\CMS\Frontend\ContentObject\TemplateContentObject->render#943 // TYPO3\CMS
      \Frontend\ContentObject\ContentObjectRenderer->cObjGetSingle#130 // TYPO3\CM
      S\Frontend\ContentObject\ContentObjectRenderer->render#859 // TYPO3\CMS\Fron
      tend\ContentObject\ContentContentObject->render#943 // TYPO3\CMS\Frontend\Co
      ntentObject\ContentObjectRenderer->cObjGetSingle#97 // TYPO3\CMS\Frontend\Co
      ntentObject\ContentObjectRenderer->cObjGetSingle#841 // TYPO3\CMS\Frontend\C
      ontentObject\ContentObjectRenderer->render#859 // TYPO3\CMS\Frontend\Content
      Object\CaseContentObject->render#943 // TYPO3\CMS\Frontend\ContentObject\Con
      tentObjectRenderer->cObjGetSingle#44 // TYPO3\CMS\Frontend\ContentObject\Con
      tentObjectRenderer->cObjGetSingle#841 // TYPO3\CMS\Frontend\ContentObject\Co
      ntentObjectRenderer->render#859 // TYPO3\CMS\Frontend\ContentObject\FluidTem
      plateContentObject->render#943 // TYPO3\CMS\Frontend\ContentObject\FluidTemp
      lateContentObject->renderFluidView#102 // TYPO3\CMS\Fluid\View\AbstractTempl
      ateView->render#300 // FluidCache_Standalone_layout_HeaderContentFooter_05d5
      9c5fba40a9be0cd9c35811f049f6b1f89141->render#189 // TYPO3\CMS\Fluid\ViewHelp
      ers\RenderViewHelper::renderStatic#63 // TYPO3\CMS\Fluid\View\AbstractTempla
      teView->renderSection#121 // FluidCache_Standalone_template_file_List_b3143f
      34b80593375f84002a7d854de17fa1585e->section_040f06fd774092478d450774f5ba30c5
      da78acc8#230 // TYPO3\CMS\Fluid\Core\ViewHelper\AbstractViewHelper->initiali
      zeArgumentsAndRender#47 // TYPO3\CMS\Fluid\Core\ViewHelper\AbstractViewHelpe
      r->callRenderMethod#249 ...' (2981 chars)
array(4 items)
   caller => 'TYPO3\CMS\Core\Database\DatabaseConnection::exec_SELECTquery' (60 chars)
   ERROR => 'Disk full (/tmp/#sql_2d4_0.MAI); waiting for someone to free some space... (
      errno: 28 "No space left on device")' (112 chars)
   lastBuiltQuery => 'SELECT  uid, pid, title, short, datetime, archivedate, type, page, ext_url, 
      sys_language_uid, l18n_parent, tt_news_related_mm.tablenames, image, bodytex
      t FROM tt_news_related_mm, tt_news WHERE ((tt_news_related_mm.uid_local=34
	
      				AND tt_news.uid=tt_news_related_mm.uid_foreign
					AND tt_news_related_
      mm.tablenames!='pages')
					OR (tt_news_related_mm.uid_foreign=34
						AND
       tt_news.uid=tt_news_related_mm.uid_local
						AND tt_news_related_mm.table
      names!='pages')) AND tt_news.deleted=0 AND tt_news.t3ver_state<=0 AND tt_new
      s.pid<>-1 AND tt_news.hidden=0 AND tt_news.starttime<=1778724840 AND (tt_new
      s.endtime=0 OR tt_news.endtime>1778724840) AND (tt_news.fe_group='' OR tt_ne
      ws.fe_group IS NULL OR tt_news.fe_group='0' OR FIND_IN_SET('0',tt_news.fe_gr
      oup) OR FIND_IN_SET('-1',tt_news.fe_group)) ORDER BY datetime desc' (826 chars)
   debug_backtrace => '{closure}#34 // TYPO3\CMS\Frontend\Http\Application->run#33 // TYPO3\CMS\Cor
      e\Core\Bootstrap->handleRequest#78 // TYPO3\CMS\Frontend\Http\RequestHandler
      ->handleRequest#307 // TYPO3\CMS\Frontend\Page\PageGenerator::renderContent#
      216 // TYPO3\CMS\Frontend\ContentObject\ContentObjectRenderer->cObjGet#210 /
      / TYPO3\CMS\Frontend\ContentObject\ContentObjectRenderer->cObjGetSingle#805 
      // TYPO3\CMS\Frontend\ContentObject\ContentObjectRenderer->render#859 // TYP
      O3\CMS\Frontend\ContentObject\TemplateContentObject->render#943 // TYPO3\CMS
      \Frontend\ContentObject\ContentObjectRenderer->cObjGetSingle#130 // TYPO3\CM
      S\Frontend\ContentObject\ContentObjectRenderer->render#859 // TYPO3\CMS\Fron
      tend\ContentObject\ContentContentObject->render#943 // TYPO3\CMS\Frontend\Co
      ntentObject\ContentObjectRenderer->cObjGetSingle#97 // TYPO3\CMS\Frontend\Co
      ntentObject\ContentObjectRenderer->cObjGetSingle#841 // TYPO3\CMS\Frontend\C
      ontentObject\ContentObjectRenderer->render#859 // TYPO3\CMS\Frontend\Content
      Object\CaseContentObject->render#943 // TYPO3\CMS\Frontend\ContentObject\Con
      tentObjectRenderer->cObjGetSingle#44 // TYPO3\CMS\Frontend\ContentObject\Con
      tentObjectRenderer->cObjGetSingle#841 // TYPO3\CMS\Frontend\ContentObject\Co
      ntentObjectRenderer->render#859 // TYPO3\CMS\Frontend\ContentObject\FluidTem
      plateContentObject->render#943 // TYPO3\CMS\Frontend\ContentObject\FluidTemp
      lateContentObject->renderFluidView#102 // TYPO3\CMS\Fluid\View\AbstractTempl
      ateView->render#300 // FluidCache_Standalone_layout_HeaderContentFooter_05d5
      9c5fba40a9be0cd9c35811f049f6b1f89141->render#189 // TYPO3\CMS\Fluid\ViewHelp
      ers\RenderViewHelper::renderStatic#63 // TYPO3\CMS\Fluid\View\AbstractTempla
      teView->renderSection#121 // FluidCache_Standalone_template_file_List_b3143f
      34b80593375f84002a7d854de17fa1585e->section_040f06fd774092478d450774f5ba30c5
      da78acc8#230 // TYPO3\CMS\Fluid\Core\ViewHelper\AbstractViewHelper->initiali
      zeArgumentsAndRender#47 // TYPO3\CMS\Fluid\Core\ViewHelper\AbstractViewHelpe
      r->callRenderMethod#249 ...' (2946 chars)
Medical Informatics Laboratory

News

MILA-Seminar - Quantitative analysis of drug effects at the whole-body level: a case study for glucose metabolism in malaria patients

Our next MILA-Seminar will take place on June 13th, 2023, from 2-3 p.m.

Speaker: Prof. Jacky Snoep (Stellenbosch University)

Title:Quantitative analysis of drug effects at the whole-body level: a case study for glucose metabolism in malaria patients

 

Malaria affected an estimated 241 million people in 2020, up from 227 million in 2019 with the highest impact in the WHO African Region which accounts for 95% of cases. In 2020 malaria deaths were estimated at 627 000. Of the four Plasmodium species that cause malaria, Plasmodium falciparum is still the most frequently occurring and the most lethal (2). An additional issue of concern is that malaria is gaining resistance to the current artemisinin combination therapies, especially evident in the African region (1), and new drugs, and methods to measure efficacy are important.

Analysis of whole-body responses to partial inhibition with a drug of one or more reaction steps is challenging; typically, mathematical models at the whole-body level are not fine-grained and do not include individual chemical reaction steps. We propose a hierarchical modelling approach to construct models for disease states at the whole-body level. Such models can simulate effects of drug-induced inhibition of reaction steps on the whole-body physiology. We illustrate the approach for glucose metabolism in malaria patients, by merging two detailed kinetic models for glucose metabolism in the parasite Plasmodium falciparum and the human red blood cell with a coarse-grained model for whole-body glucose metabolism. Particular attention will be paid to model construction, validation, reproducible simulation and data management for the detailed models.

The Snoep Lab’s core research efforts are in Computational Systems Biology; a combined experimental, modeling and theoretical approach to quantitatively understand the functional behavior of Biological Systems resulting from the characteristics of their components. Our main focus is on metabolism of human pathogens, such as  Plasmodium falciparum, Mycobacterium tuberculosis, and on modelling disease states such as type 2 diabetes and HIV pathogenesis at a whole body level.

  • This is a f2f seminar at the Main Building University Medicine (Hörsaal Nord)
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